Vietnam
Japanese Encephalitis

Vietnam: Selective Vaccinations

Japanese Encephalitis

Country Risk

Japanese Encephalitis is endemic throughout Vietnam. Transmission occurs from May to October. Most cases occur in the south during the rainy and early dry season; and in the north during late summer and autumn.

Description

Japanese Encephalitis is a viral infection caused by RNA viruses belonging to the Flavivirus genus. It is a zoonosis – an animal disease that can spread to humans – primarily transmitted by evening biting Culex mosquitoes that feed on infected birds, pigs and other mammals passing the infection to humans living and working in rural areas around rice paddies and irrigation systems.

Risk

Japanese Encephalitis occurs in Southeast Asia. Long-term travellers, persons involved in outdoor recreational activities or on work assignments going to endemic areas are at risk, especially those visiting rural areas, farms, rice fields and irrigation areas. Children under 15 years of age seem to particularly susceptible to the infection. Outbreaks typically occur during or shortly after the rainy season in temperate regions and year-round in tropical regions (peak transmission during summer months).

Symptoms

The majority of cases are asymptomatic – persons do not exhibit symptoms. Those with symptoms usually get ill 5 to 15 days after exposure to the virus. Symptoms include fever, severe headache, vomiting, diarrhea, and general weakness. Some patients will develop neurological symptoms such as tremors, seizures (especially children), expressionless face, and sudden paralysis which can affect the respiratory system and cause bladder retention problems. Patients may also experience behavioural changes which can be misdiagnosed as psychiatric illness. Japanese Encephalitis can be fatal in 20% to 30% percent of cases and many survivors continue to have long-term neurologic, psychiatric, or cognitive problems. Treatment includes supportive care of symptoms.

Prevention
  • Use a repellent containing 20%-30% DEET or 20% Picaridin on exposed skin. Re-apply according to manufacturer's directions.
  • Wear neutral-coloured (beige, light grey) clothing. If possible, wear long-sleeved, light-weight garments.
  • If available, pre-soak or spray outer layer clothing and gear with permethrin.
  • Get rid of water containers around dwellings and ensure that door and window screens work properly.
  • Apply sunscreen first followed by the repellent (preferably 20 minutes later).
  • For more details, see IAMAT's insect bite prevention.
Vaccination

Recommended for persons travelling extensively in rural areas, long-term travellers, and persons on work assignments in endemic areas.

The inactivated Vero cell vaccine is available in select countries. Booster vaccination is recommended 1-2 years if you are at continued risk of exposure. Live attenuated vaccines are available in Japanese Encephalitis endemic countries where they are given as part of the childhood routine immunization schedule. Discuss your options with a healthcare provider if you can’t finish the vaccination series before departure.


Information last updated: March 02, 2021.

  • Solomon T. Japanese Encephalitis. In: McGill, A; Ryan, E; Hill, D; Solomon, T, eds. Hunter's Tropical Medicine and Emerging Infectious Diseases. 9th ed. New York: Saunders Elsevier; 2013: 358-365.
  • Centres for Disease Control and Prevention: Yellow Book, Japanese Encephalitis
  • Public Health Agency of Canada: Canadian Immunization Guide, Japanese Encephalitis Vaccine
  • World Health Organization: International Travel and Health, Vaccine Preventable Diseases and Vaccines